Synthesis, Characterization, and Cytotoxicity study of Some Pyridine Chalcone Derivatives
Journal of Basrah Researches (Sciences),
Volume 45, Issue 1, Pages 14-31
AbstractCurrently, chalcone derivatives are an interest research for the designing a new compounds as anticancer agents due to the privilate structure of chalcone compounds in the drug discovery system. In this study, we synthesized 5 chalcone derivates which are (CH (A) , CH (B) , CH (C) , CH (E) , and CH (D)) from the reaction of substituted acetophenone with 2- pyridine carboxyaldehyde by using Claisen- Schmidt condensation method and catalyze the reaction by KOH pellets. After purification process, the yield was good to characterize them by using chemical structure analysis (FTIR, C13NMR, Mass spectrum), which approved their structures. Cytotoxicity evaluation was with 100 µM for each concentration compound against Human Breast Cancer MDA-MB231 Cells and we identified two pyridine chalcone derivatives showed a moderate action. The results of toxicity evaluation pave a forward step to develop new anticancer agents as from pyridine chalcones as a lead structure.
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